Applied Biosystems 3500/3500xL Series Data…: Missing Support for Integrity Check
CVE-2026-17583 is a high-severity missing support for integrity check vulnerability in Applied Biosystems 3500/3500xL Series Data Collection Software from Thermo Fisher, with a CVSS 3.1 base score of 8.4 out of 10. It can be exploited with local access to the system by an unauthenticated attacker, without any action from a user. Affected Applied Biosystems 3500/3500xL Series Data Collection Software versions: 4.0.2 and earlier. The record does not name a fixed version, so check the vendor advisory. There is no confirmed exploitation so far. EPSS estimates a 0.14% chance of exploitation within 30 days, which is low compared with other CVEs.
High severity with no evidence of exploitation so far.
What to do
- Update Genemapper Id-x to 1.7.4 or a later version.
- Read the advisory on documents.thermofisher.com for workarounds and exact fixed builds.
Affected products and versions
| Vendor | Product | Affected versions | Fixed in |
|---|---|---|---|
| Thermo Fisher | Applied Biosystems 3500/3500xL Series Data Collection Software | 4.0.2 and earlier | Not stated |
| Thermo Fisher | Applied Biosystems 3730/3730xL Series Data Collection Software | 5.0.2 and earlier | Not stated |
| Thermo Fisher | Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software | 1.2.5 and earlier | Not stated |
| Thermo Fisher | Applied Biosystems SeqStudio Flex Series Instrument Software | 1.2.0 and earlier | Not stated |
| Thermo Fisher | Applied Biosystems GeneMapper ID-X Software | 1.7.3 and earlier | Not stated |
| Thermo Fisher | Applied Biosystems 3130 Series Data Collection Software | 4.1 and earlier | Not stated |
| Thermo Fisher | ABI PRISM 3100/3100-Avant Data Collection Software | 2.0 and earlier | Not stated |
| Thermo Fisher | ABI PRISM 310 Data Collection Software | 3.1 and earlier | Not stated |
| Thermofisher | Genemapper Id-x | before 1.7.4 | 1.7.4 |
Version data comes from the organisation that assigned the CVE. Confirm against the vendor advisory before deciding you are unaffected.
How the severity score breaks down
- Attack vector
- LocalThe attacker needs local access or must trick a user into running something.
- Attack complexity
- LowNo special conditions are needed; the attack works reliably.
- Privileges required
- NoneNo account or login is needed.
- User interaction
- NoneNo action by a victim is required.
- Scope
- UnchangedImpact stays within the vulnerable component.
- Confidentiality
- HighAll data handled by the component can be read.
- Integrity
- HighData or code can be modified at will.
- Availability
- HighThe component can be taken down completely.
Vector: CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H. Scored by CNA (hq.dhs.gov).
| Scoring system | Score | Severity | Scored by |
|---|---|---|---|
| CVSS 4.0 | 8.3 | High | CNA (hq.dhs.gov) |
| CVSS 3.1 | 8.4 | High | CNA (hq.dhs.gov) |
Official description
The affected Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.
Source: the CVE record as published by its numbering authority, via NVD and CVE.org.
The underlying weakness: Missing Support for Integrity Check
The product uses a transmission protocol that does not include a mechanism for verifying the integrity of the data during transmission, such as a checksum.
How developers prevent this class of flaw
- Add an appropriately sized checksum to the protocol, ensuring that data received may be simply validated before it is parsed and used.
- Ensure that the checksums present in the protocol design are properly implemented and added to each message before it is sent.
More Missing Support for Integrity Check vulnerabilities (CWE-353)
Timeline
- CVE record published.
- CISA published its SSVC assessment (exploitation: none, automatable: no, technical impact: total).
- Record last changed materially (score, affected products, status or references).
References
Patches and release notes
- cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01Third Party Advisory, US Government Resource
Third-party and government advisories
- cve.org/CVERecord?id=CVE-2026-17583Third Party Advisory
Recent Missing Support for Integrity Check vulnerabilities
- 7.5 High severity
- 8.7 High severity
- 7.1 High severity
- 9.1 Critical severity
- 7.3 High severity
- 8.1 High severity
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